ISR-alpha anticorps (Extracellular Domain) (CF®640R)

N° du produit ABIN7655320

Cet anticorps Souris Monoclonal détecte spécifiquement ISR-alpha dans . Il présente une réactivité envers Humain.

Aperçu rapide pour ISR-alpha anticorps (Extracellular Domain) (CF®640R) (ABIN7655320)

Antigène: ISR-alpha (Insulin Receptor alpha (ISR-alpha))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ISR-alpha est conjugé à/à la CF®640R

Application: Veuillez nous consulter SVP

Clone: INSR-1661

Détail du produit anti-ISR-alpha anticorps (CF®640R)

Épitope: Extracellular Domain

Fonction: Insulin Receptor Alpha(INSR/1661), CF640R conjugate

Attributs du produit: The insulin receptor (INSR) is a heterodimeric protein complex that has an intracellular subunit, which is disulfide-linked to a transmembrane segment. The insulin ligand binds to the INSR and initiates molecular signaling pathways that promote glucose uptake in cells and glycogen synthesis. Insulin binding to INSR induces phosphorylation of intra-cellular tyrosine kinase domains and recruitment of multiple SH2 and SH3 domain-containing intracellular proteins that serve as signaling intermediates for pleiotropic effects of insulin. Type 1 diabetes is an autoimmune condition of the endocrine pancreas that results in destruction of insulin secreting cells and a progressive loss in insulin-sensitive glucose uptake by cells. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogène: Recombinant fragment of extracellular domain of human Insulin Receptor alpha

Isotype: IgG1, kappa

Information d'application

Indications d'application: For coating for ELISA, order Ab without BSA. Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody. Optimal dilution and staining procedure for a specific application should be determined by user. Recommended starting concentrations for titration are 1-2 μg/mL for most applications, or 1 μg/million cells/100 μLfor flow cytometry

Commentaires:

Positive Control: Jurkat cells. Human pancreas.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.1 mg/mL

Buffer: PBS, 0.1 % BSA, 0.05 % azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Protect from light

Stock: 4 °C

Stockage commentaire:

Stable at room temperature or 37°C for 7 days.

Protect from light

Store at 2 to 8°C. Protect fluorescent conjugates from light

Date de péremption: 24 months

Détails sur ISR-alpha

Antigène: ISR-alpha (Insulin Receptor alpha (ISR-alpha))

Autre désignation: Insulin Receptor Alpha

Sujet:

Synonyms: CD220, HHF5, HINSR A, INSR, Insulin receptor, Insulin receptor subunit alpha, INSR

Gene Symbol: INSR

Poids moléculaire: 135 kDa

ID gène: 3643

UniProt: P06213